An aptamer discovery pipeline – new opportunities with SBCF

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APTASTRUCT – an aptamer discovery pipeline to target SARS-CoV-2 proteins for detection, diagnostics, and therapy.

Our over one-year battle against SARS CoV-2 virus has proven that immediate action from the scientific communities around the globe can and is helping in understanding and fighting down the virus. However, as evolution promotes new variants to appear, this requires the development of highly modifiable and adaptable tools to recognize and kill the pathogen. This is why Structural Biology Core Facility decided to set up a pipeline to develop and characterize highly specific oligonucleotide aptamers, which are capable of binding coronavirus proteins. These aptamers can be directly used as biosensors, act as inhibitors, or could be fused to functional modules that allow detection or inhibition after specific recognition. We hope to select aptamers distinguishing SARS CoV-2 from other coronaviruses as well as recognizing different SARS CoV-2 variants. An established pipeline will be included into the portfolio of our Structural Biology Core Facility and can be used to select aptamers for any protein.

We have put on this project our two tRNA specialists Anna Biela and Dominika Dobosz, together with an external expert Stanisław Malicki. The team already delivers interesting preliminary results.

Written by Anna Biela