Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Updated photo of Glatt Lab group members
We finally managed to gather (almost) all of our group members in the one picture! Have a look: READ MORE
A visiting student from the University of Kassel joins us for 2 months
Maria Landrock joins Max Planck Research Group for 2 months to take advantage of the research experience available in our laboratory. We are also very happy to have Maria here, which help us... READ MORE
Regulating the Regulator
A team of scientists from the Małopolska Centre of Biotechnology (MCB) at the Jagiellonian University (Kraków, Poland) has identified a potential link between tRNA modifications and the biosynthesis of selenocysteine, the 21st naturally... READ MORE
Our team publishes Elp3 protein structure in Nature Communications!
An International team of researchers based at the Malopolska Centre of Biotechnology (MCB) from the Jagiellonian University in Krakow, Poland, has cracked the atomic structure of an important cellular “bodyguard”. The Elp3 protein... READ MORE