Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Several of our team members proudly presented their work on the 24th Annual Meeting of RNA Society in Krakow
The annual RNA meeting is quite a magnificent meeting for the RNA people to gather around and discuss their findings. This great meeting had over 1000 participant this year and took place at... READ MORE
The 2nd Summer School of the Malopolska Centre of Biotechnology
On 23rd and 24th of May, the whole Institute enjoyed a two-day seminar in the heart of the Tatry mountains – the town of Zakopane. About 140 participants contributed to 90 poster presentations... READ MORE
Updated photo of Glatt Lab group members
We finally managed to gather (almost) all of our group members in the one picture! Have a look: READ MORE
A visiting student from the University of Kassel joins us for 2 months
Maria Landrock joins Max Planck Research Group for 2 months to take advantage of the research experience available in our laboratory. We are also very happy to have Maria here, which help us... READ MORE