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Welcome to the Max Planck Research Group website!

 

Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.

crystals under microscope

Crystallography

We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.

tRNA modification

We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.

elongator-structure

Electron microscopy

Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.

Cell culture

We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.

Latest News

Malopolska Researchers Night 2018

   Once again the members of Max Planck Research Group participated in the organization of the Malopolska Researchers Night at the Malopolska Centre of Biotechnology. On the 28th of September, we were visited... READ MORE