Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Our team publishes Elp3 protein structure in Nature Communications!
An International team of researchers based at the Malopolska Centre of Biotechnology (MCB) from the Jagiellonian University in Krakow, Poland, has cracked the atomic structure of an important cellular “bodyguard”. The Elp3 protein... READ MORE
Meet Igor Kaczmarczyk, a new visiting student in our lab.
Igor joined our group as a visiting student to work on reconstitution of murine elongator complex in insect cells. Igor says about himself: I am a student of BA program in biotechnology at... READ MORE
Brand new review from our lab!
Our 2nd Year Ph.D. Student Raj (Keerthiraju Ethiraju Ravichandran), along with research collaborator Prof. Dr. Raffael Schaffrath and his team members from Kassel, Germany have just published a review article entitled “Roles of Elongator... READ MORE
Jarek Mazur, our Master Student granted with Ministry Stipend!
We are proud to announce that our Master student Jarosław Mazur was granted a scholarship by the Minister of Science and Higher Education for outstanding achievements for the 2018/2019 academic year. Only 656... READ MORE