Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
ETIUDA grant for Anna Salerno-Kochan
A PhD Student from Max Planck Research Group at MCB – Anna Salerno-Kochan – has been awarded with ETIUDA grant for young scientists who are preparing a doctoral dissertation. The project titled... READ MORE
A tRNA modifier at work
Our team members using cryo-electron microscopy (cryo-EM) managed to catch Elongator directly at work. They published their results in Science Advances. All living cells employ ribosomes and transfer RNA (tRNA) molecules to decode... READ MORE
Several of our team members proudly presented their work on the 24th Annual Meeting of RNA Society in Krakow
The annual RNA meeting is quite a magnificent meeting for the RNA people to gather around and discuss their findings. This great meeting had over 1000 participant this year and took place at... READ MORE
The 2nd Summer School of the Malopolska Centre of Biotechnology
On 23rd and 24th of May, the whole Institute enjoyed a two-day seminar in the heart of the Tatry mountains – the town of Zakopane. About 140 participants contributed to 90 poster presentations... READ MORE