Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Postgraduate School of Molecular Medicine at MCB
On 12th to 14th of November, our group members co-organized and participated in Postgraduate School of Molecular Medicine – Autumn School in Krakow. The topic of the conference for Ph.D. students was “High... READ MORE
A revolutionary research technology for Cryo-electron microscopy at the SOLARIS Center!
25th of October 2018, will go down in history not only for the National Synchrotron Radiation Center SOLARIS, but also for the entire Polish scientific community. On that day, the Ministry of Science... READ MORE
Meet our new group member, Tomasz Gawda, Master student
A new Master student, Tomasz Gawda, joined our group this month. Tomek will be working with Monika Gaik on the project focused on structural and functional characterization of patient-derived mutations in an essential... READ MORE
Best Oral Presentation Award for Dr. Ting-Yu Lin
Dr. Ting-Yu Lin oral presentation titled: “The noncanonical tRNA acetyltransferase activity of Elongator complex subunit 3” has been recognized for excellence at 27th tRNA Conference in Strasbourg, France. She presented her recent... READ MORE