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Welcome to the Max Planck Research Group website!

 

Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.

crystals under microscope

Crystallography

We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.

tRNA modification

We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.

elongator-structure

Electron microscopy

Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.

Cell culture

We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.

Latest News

A living molecular fossil
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An international team of researchers from the Max Planck Research Group at the Malopolska Centre of Biotechnology (MCB) deciphered the molecular mechanism of a sulfur carrier system that stands at the root of... READ MORE

PhD School

Ph.D. opportunities in Glatt Lab
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Are you interested in structural biology? Do you want to work in the international, world-class institute and publish in the best scientific journals? Max Planck Research Group at Malopolska Centre of Biotechnology has... READ MORE