Max Planck Research Group MCB blurred

Welcome to the Max Planck Research Group website!

 

Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.

crystals under microscope

Crystallography

We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.

tRNA modification

We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.

elongator-structure

Electron microscopy

Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.

Cell culture

We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.

Latest News

Jarosław Mazur defends his Master Thesis!

One of our Master Students – Jarosław Mazur – defended his Master Thesis last week at the Faculty of Biochemistry, Biophysics, and Biotechnology. His Master Thesis titled: “Functional characteristics of casein kinase Hrr25... READ MORE

Glatt Lab Xmas Party

This year Glatt Lab and Structural Biology Core Facility members celebrated together the festive season in Hotel Wilga Restaurant in Krakow.  After a delicious dinner, we moved downstairs to enjoy playing games such... READ MORE

Lab Retreat – October 2019

This year 3 groups got together One of our group traditions is a lab retreat. Each year, together with Maria Górna’s lab from Warsaw (another RNA-oriented team) we go for a few days... READ MORE