Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Same but different — Molecular comparison of human KTI12 and PSTK
We are happy to announce a new paper from our Team, focusing on two interesting proteins – human Kti12 and PSTK. Kti12 and PSTK are highly similar proteins implicated in different aspects of... READ MORE
A new Team Member – Priyanka Dahate
We have a great pleasure to introduce our new Team Member – Priyanka Dahate, who joined Max Planck Research Group as a PhD student within the Implementation PhD programme in collaboration with a... READ MORE
Is Elp3 the wild child of acetyltransferases?
Last November scientists from Glatt lab compiled together the latest advances on Elongator protein 3 (Elp3) and its acetyl-transferase activity. The aim of Abbassi et al.’s review was to explain more clearly the... READ MORE
A new Team Member – Rahul Mehta
We have a great pleasure to introduce our new Team Member – Rahul Mehta, who joined Max Planck Research Group as a PhD student. He will work with us on a project focused... READ MORE