Max Planck Research Group MCB blurred

Welcome to the Max Planck Research Group website!

 

Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.

crystals under microscope

Crystallography

We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.

tRNA modification

We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.

elongator-structure

Electron microscopy

Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.

Cell culture

We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.

Latest News

TVP visiting Glatt Lab

Here at Glatt Lab we believe that science should not be limited to the walls of our laboratory. This is why a few weeks ago we had a pleasure to host a journalists... READ MORE

Literature weeks at Glatt Lab

In recent weeks, when the infection rates of SARS-CoV-2 in Poland skyrocketed and forced our lab members to minimize contact and stay home, we came up with an idea to take advantage of... READ MORE