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Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
Ph.D. opportunities in Glatt Lab
Are you interested in structural biology? Do you want to work in the international, world-class institute and publish in the best scientific journals? Max Planck Research Group at Malopolska Centre of Biotechnology has... READ MORE
Polish edition of the French 3-minute thesis contest
We have the pleasure to announce that one of our PhD students, Nour-el-hana Abbassi is competing in the French “Ma thèse en 180s” contest. The aim is to explain to the general public... READ MORE
Research on hypusination awarded again
The National Science Centre has granted 209 412 PLN for research on deoxyhupusine synthase (DHS) within the 18th edition of Preludium grant. The research will be conducted by Elżbieta Wątor, a 1st year... READ MORE
Prestigious START scholarships in Glatt Lab
Rościsław Krutyhołowa, one of our PhD students, has been awarded prestigious and one of the oldest scholarships from The Foundation For Polish Science – START. The scholarship is granted to young and ambitious... READ MORE