Welcome to the Max Planck Research Group website!
Research in the Glatt lab combines structural biology (x-ray crystallography and electron microscopy), molecular biology, protein biochemistry, biophysics, and cell biology to understand specific regulatory mechanisms of protein synthesis.
Crystallography
We use X-ray crystallography to study how proteins interact with other molecules (i.e. tRNA) and gain detailed knowledge about macromolecular assemblies and their role in post-transcriptional regulation.
tRNA modification
We are interested in the Elongator complex-mediated cm5 modification on the uridine 34 at wobble position of tRNA anticodon loop.
Electron microscopy
Topological models of the Elp123-subcomplex and the Elongator complex obtained by combining the available crystal structures and homology models with EM and XL-MS data.
Cell culture
We work mainly on HEK293 cells that are our source of human tRNAs and human proteins involved in tRNA modification process. Our main techniques are transfection and lentiviral transduction to modulate levels of proteins of interest.
Latest News
A Sonata grant for Dr. Ting-Yu Lin
Dr. Ting Yu-Lin from our Team has been awarded with a Sonata grant from National Science Center for the realization of her project “Molecular and structural insight into the human pseudouridine synthase 3”.... READ MORE
We are hiring!
We are looking for an excellent researcher to join our team! Apply HERE – https://www.nature.com/naturecareers/job/postdoc-position-in-the-max-planck-research-group-funded-by-an-erc-consolidator-grant-to-sebastian-glatt-jagiellonian-university-uj-740920 READ MORE
New study unravels a link between mutations in Elongator and neurodevelopmental disorders
A group of scientists from the Max Planck Research Group at the Malopolska Centre of Biotechnology (MCB) of the Jagiellonian University in collaboration with the University of Queensland from Brisbane, Australia has shed... READ MORE
An aptamer discovery pipeline – new opportunities with SBCF
APTASTRUCT – an aptamer discovery pipeline to target SARS-CoV-2 proteins for detection, diagnostics, and therapy. Our over one-year battle against SARS CoV-2 virus has proven that immediate action from the scientific communities around... READ MORE