The research will focus on the search for a group of enzymes reversing one of the evolutionally oldest protein modifications, known as urmylation. The latest studies have shown that this process is one of the most important mechanisms protecting cells from oxidative stress. Whereas the molecular basis of the modification has been known, no enzyme reversing the process has been identified so far. In Dr Kwaśna’s project, specific active probes reacting with the targeted group of enzymes will be developed. The captured proteins will be identified by means of mass spectrometry, and further research will concentrate on understanding the mechanism of their functioning and the role they play in cells.
Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them.
EU contribution: 139 953,60 EUR
Programme: HE Main Work Programme 2021–2022 – 11. Widening participation and strengthening the European Research Area
Funding call: HORIZON-WIDERA-2022-TALENTS-02
Funding period: 1st July 2022 – 30th June 2024
ERA Consolidator Grant- View News